glutamate derivative

By Targets:	iGluR (2) Amino Acid Derivatives (9) Antibiotic (1) Biochemical Assay Reagents (1) Cholinesterase (ChE) (1) Endogenous Metabolite (1) HDAC (1) HSP (1) Parasite (1) Reactive Oxygen Species (2) Tau Protein (1)
By Research Areas:	Cancer (4) Infection (1) Metabolic Disease (2) Neurological Disease (7)
Click Chemistry:	Alkynes (1)

Targets Recommended: mGluR iGluR EAAT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0749A

Dimethyl D-glutamate hydrochloride

Glutamic acid, dimethyl ester, hydrochloride, D-
Amino Acid Derivatives Others

Dimethyl D-glutamate hydrochloride is a glutamic acid derivative .
HY-W010785

Dibenzyl L-glutamate tosylate

Amino Acid Derivatives Others

Dibenzyl L-glutamate tosylate is a glutamic acid derivative .
HY-30232

L-Glutamate-γ-benzyl ester

Amino Acid Derivatives Others

L-Glutamate-γ-benzyl ester is a glutamic acid derivative .

Dimethyl D-glutamate hydrochloride Glutamic acid, dimethyl ester, hydrochloride, D-	Amino Acid Derivatives	Others
Dimethyl D-glutamate hydrochloride is a glutamic acid derivative .

Dibenzyl L-glutamate tosylate	Amino Acid Derivatives	Others
Dibenzyl L-glutamate tosylate is a glutamic acid derivative .

L-Glutamate-γ-benzyl ester	Amino Acid Derivatives	Others
L-Glutamate-γ-benzyl ester is a glutamic acid derivative .

HY-131039

MDNI-caged-L-glutamate MDNI-glu	Amino Acid Derivatives	Others
MDNI-caged-L-glutamate (MDNI-glu) is a biologically inert, photosensitive derivative of the major excitatory amino acid, L-glutamate. MDNI-caged-L-glutamate makes more efficient use of incident light .

HY-W745139

5-Octyl D-Glutamate

Amino Acid Derivatives Others

5-Octyl D-Glutamate is aamino acids and their derivatives.
HY-W025811

1-(tert-Butyl) 5-methyl L-glutamate hydrochloride

Amino Acid Derivatives Others

1-(tert-Butyl) 5-methyl L-glutamate hydrochloride is a glutamic acid derivative .
HY-W008326

Z-Glu(OtBu)-OH

Amino Acid Derivatives Others

Z-Glu(OtBu)-OH is a derivative of glutamate, can be used for molecule, agent, compounds synthesis .
HY-20167A

H-Glu(OtBu)-OtBu hydrochloride

H-Glu(OtBu)-OtBu hydrochloride is a glutamate derivative that can be used for substance P antagonist synthesis .
HY-W022255

Fmoc-D-Glu-OH

D-Fmoc-glutamic acid
Amino Acid Derivatives Others

Fmoc-D-Glu-OH (D-Fmoc-glutamic acid) is a derivative of glutamate, can be used to prepare supramolecular hydrogels .
HY-20167

H-Glu(OtBu)-OtBu

Amino Acid Derivatives Others

H-Glu(OtBu)-OtBu is a glutamic acid derivative .

5-Octyl D-Glutamate	Amino Acid Derivatives	Others
5-Octyl D-Glutamate is aamino acids and their derivatives.

1-(tert-Butyl) 5-methyl L-glutamate hydrochloride	Amino Acid Derivatives	Others
1-(tert-Butyl) 5-methyl L-glutamate hydrochloride is a glutamic acid derivative .

Z-Glu(OtBu)-OH	Amino Acid Derivatives	Others
Z-Glu(OtBu)-OH is a derivative of glutamate, can be used for molecule, agent, compounds synthesis .

H-Glu(OtBu)-OtBu hydrochloride
H-Glu(OtBu)-OtBu hydrochloride is a glutamate derivative that can be used for substance P antagonist synthesis .

Fmoc-D-Glu-OH D-Fmoc-glutamic acid	Amino Acid Derivatives	Others
Fmoc-D-Glu-OH (D-Fmoc-glutamic acid) is a derivative of glutamate, can be used to prepare supramolecular hydrogels .

H-Glu(OtBu)-OtBu	Amino Acid Derivatives	Others
H-Glu(OtBu)-OtBu is a glutamic acid derivative .

HY-U00127

Pyridazinediones-derivative-1	Others	Neurological Disease
Pyridazinediones-derivative-1 has potential in treating neurodegenerative disorders. It shows an ED₅₀ of 2.1 μM for inhibiting glutamate-induced contractions of isolated guineapig ileum.

HY-134136

Octanoyl Coenzyme A	Endogenous Metabolite	Metabolic Disease
Octanoyl coenzyme A is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC₅₀ values of 0.4-1.6 mM .

HY-N8115

S-(4-Hydroxybenzyl)glutathione	Others	Neurological Disease
S-(4-Hydroxybenzyl)glutathione is a glutathione derivative. S-(4-Hydroxybenzyl)glutathione inhibits the in vitro binding of kainic acid to brain glutamate receptors, with an IC₅₀ of 2 μM .

HY-134136A

Octanoyl coenzyme A lithium	Biochemical Assay Reagents	Cancer
Octanoyl coenzyme A lithium is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A lithium can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC₅₀ values of 0.4-1.6 mM .

HY-101311

UPF-523 AIDA
UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC₅₀ of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis .

HY-15067

DNQX 4 Publications Verification FG 9041	iGluR	Cancer
DNQX (FG 9041), a quinoxaline derivative, is a selective, potent competitive *non-NMDA glutamate* receptor antagonist (IC₅₀**s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively) .

HY-103233

DNQX disodium salt FG 9041 disodium salt	iGluR	Cancer
DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive *non-NMDA glutamate* receptor antagonist (IC₅₀**s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively) .

HY-162340

Z32439948	Cholinesterase (ChE)	Neurological Disease
Z32439948 is a butyrylcholinesterase (BChE) inhibitor (IC₅₀: 1.4 μM, hBChE) and is a derivative of m-sulfamoylbenzamide. Z32439948 also exhibited neuroprotective effects against glutamate in SH-SY5Y cells .

HY-100547

IEM-1754
IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo .

HY-B0778

Milbemycin oxime	Antibiotic Parasite	Infection
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

HY-122723

GOT1 inhibitor-1 1 Publications Verification	Others	Cancer
GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC₅₀ of 8.2 uM. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC) .

HY-105022

Sabeluzole R 58735	Tau Protein	Neurological Disease
Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease .

HY-120251A

Leteprinim potassium AIT-082	Reactive Oxygen Species	Neurological Disease
Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species .

HY-120251

Leteprinim AIT-082 free acid	Reactive Oxygen Species	Neurological Disease
Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species .

HY-118783

2-Hexyl-4-pentynoic acid (±)-2-Hexyl-4-pentynoic acid	HDAC HSP	Neurological Disease
2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), valproic acid (VPA) derivative, exhibits potential roles of HDAC inhibition (IC₅₀=13 μM) and HSP70 induction. Potent neuroprotective effects. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons . 2-Hexyl-4-pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Type

HY-134136A

Octanoyl coenzyme A lithium	Biochemical Assay Reagents
Octanoyl coenzyme A lithium is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A lithium can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC₅₀ values of 0.4-1.6 mM .

HY-134136

Octanoyl Coenzyme A	Biochemical Assay Reagents
Octanoyl coenzyme A is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC₅₀ values of 0.4-1.6 mM .

Cat. No.	Product Name	Target	Research Area

HY-Y0749A

Dimethyl D-glutamate hydrochloride

Glutamic acid, dimethyl ester, hydrochloride, D-
Amino Acid Derivatives Others

Dimethyl D-glutamate hydrochloride is a glutamic acid derivative .
HY-W010785

Dibenzyl L-glutamate tosylate

Amino Acid Derivatives Others

Dibenzyl L-glutamate tosylate is a glutamic acid derivative .
HY-30232

L-Glutamate-γ-benzyl ester

Amino Acid Derivatives Others

L-Glutamate-γ-benzyl ester is a glutamic acid derivative .
HY-W025811

1-(tert-Butyl) 5-methyl L-glutamate hydrochloride

Amino Acid Derivatives Others

1-(tert-Butyl) 5-methyl L-glutamate hydrochloride is a glutamic acid derivative .
HY-W745139

5-Octyl D-Glutamate

Amino Acid Derivatives Others

5-Octyl D-Glutamate is aamino acids and their derivatives.
HY-W008326

Z-Glu(OtBu)-OH

Amino Acid Derivatives Others

Z-Glu(OtBu)-OH is a derivative of glutamate, can be used for molecule, agent, compounds synthesis .
HY-W022255

Fmoc-D-Glu-OH

D-Fmoc-glutamic acid
Amino Acid Derivatives Others

Fmoc-D-Glu-OH (D-Fmoc-glutamic acid) is a derivative of glutamate, can be used to prepare supramolecular hydrogels .
HY-139468

Ala-Glu-OH

Peptides Others

Ala-Glu-OH is an agent of the dipeptide .
HY-20167

H-Glu(OtBu)-OtBu

Amino Acid Derivatives Others

H-Glu(OtBu)-OtBu is a glutamic acid derivative .

Dimethyl D-glutamate hydrochloride Glutamic acid, dimethyl ester, hydrochloride, D-	Amino Acid Derivatives	Others
Dimethyl D-glutamate hydrochloride is a glutamic acid derivative .

Dibenzyl L-glutamate tosylate	Amino Acid Derivatives	Others
Dibenzyl L-glutamate tosylate is a glutamic acid derivative .

L-Glutamate-γ-benzyl ester	Amino Acid Derivatives	Others
L-Glutamate-γ-benzyl ester is a glutamic acid derivative .

1-(tert-Butyl) 5-methyl L-glutamate hydrochloride	Amino Acid Derivatives	Others
1-(tert-Butyl) 5-methyl L-glutamate hydrochloride is a glutamic acid derivative .

5-Octyl D-Glutamate	Amino Acid Derivatives	Others
5-Octyl D-Glutamate is aamino acids and their derivatives.

Z-Glu(OtBu)-OH	Amino Acid Derivatives	Others
Z-Glu(OtBu)-OH is a derivative of glutamate, can be used for molecule, agent, compounds synthesis .

Fmoc-D-Glu-OH D-Fmoc-glutamic acid	Amino Acid Derivatives	Others
Fmoc-D-Glu-OH (D-Fmoc-glutamic acid) is a derivative of glutamate, can be used to prepare supramolecular hydrogels .

Ala-Glu-OH	Peptides	Others
Ala-Glu-OH is an agent of the dipeptide .

H-Glu(OtBu)-OtBu	Amino Acid Derivatives	Others
H-Glu(OtBu)-OtBu is a glutamic acid derivative .

HY-134141

5-Octyl hydrogen L-glutamate	Peptides	Metabolic Disease
5-Octyl hydrogen L-glutamate is cell-permeable molecule and can be used for synthesizing 5-octyl ester derivatives (5-octyl α-ketoglutarate) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8115

S-(4-Hydroxybenzyl)glutathione	Structural Classification Monophenols Gastrodia elata Bl. Ketones, Aldehydes, Acids Orchidaceae Source classification Phenols Plants	Others
S-(4-Hydroxybenzyl)glutathione is a glutathione derivative. S-(4-Hydroxybenzyl)glutathione inhibits the in vitro binding of kainic acid to brain glutamate receptors, with an IC₅₀ of 2 μM .

HY-B0778

Milbemycin oxime	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Antibiotic Parasite
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

HY-134136

Octanoyl Coenzyme A	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Octanoyl coenzyme A is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC₅₀ values of 0.4-1.6 mM .

Cat. No.	Product Name		Classification

HY-118783

2-Hexyl-4-pentynoic acid (±)-2-Hexyl-4-pentynoic acid		Alkynes
2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), valproic acid (VPA) derivative, exhibits potential roles of HDAC inhibition (IC₅₀=13 μM) and HSP70 induction. Potent neuroprotective effects. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons . 2-Hexyl-4-pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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